Tessalon Usage and Pharmacokinetics

Attribute	Description
Generic Name	Benzonatate
Dosage Form	Capsules
Strength	100 mg, 200 mg
Therapeutic Class	Antitussive
Prescribing Info	Learn More About Tessalon

Pharmacokinetics of Tessalon

Contents

1 Pharmacokinetics of Tessalon

Benzonatate 100 mg acts as an antitussive agent. It exerts a local anesthetic effect on the stretch receptors located in the respiratory passages, lungs, and pleura. This mechanism reduces the cough reflex at its source. The absorption rate of benzonatate is variable, with onset of action occurring within 15 to 20 minutes post-ingestion. It can last for up to 8 hours, making it suitable for intermittent cough relief. Plasma concentrations peak quickly, which aids in fast-acting relief.

The drug undergoes hydrolysis, resulting in the formation of para-aminobenzoic acid (PABA) and other metabolites. These metabolites are excreted through renal pathways. Its metabolism does not involve cytochrome P450 enzymes, which lowers the potential for drug interactions. Benzonatate is not associated with extensive systemic effects due to minimal systemic absorption. As a result, its pharmacokinetic profile supports its targeted use in treating non-productive cough.

How Tessalon Should Be Used

Benzonatate 200 mg should be used as directed by a healthcare professional. It is critical to swallow capsules whole. Chewing or sucking on the capsules can cause local anesthesia of the oral mucosa, leading to potential adverse reactions. The typical adult dose ranges from 100 mg to 200 mg taken up to three times daily as needed for cough suppression.

Patients should follow a consistent dosing schedule and not exceed the recommended daily dosage. It is important to maintain adequate hydration during therapy. Caution is advised for patients with underlying respiratory conditions or a history of hypersensitivity reactions. Monitoring for therapeutic efficacy and potential adverse effects should occur regularly throughout the treatment duration.

Warnings & Precautions

Tessalon requires careful use in specific patient populations. Those with a history of hypersensitivity to benzonatate or related compounds should avoid its use. Accidental ingestion of benzonatate in children may result in severe and potentially fatal reactions. Therefore, the medication must be kept out of reach of children. Avoid alcohol consumption during treatment, as it may exacerbate certain side effects.

The medication can cause mental alertness impairment. Activities requiring mental concentration, such as driving, should be performed cautiously. The risk of allergic reactions exists and can manifest as skin eruptions or more severe anaphylactic responses. Immediate medical attention is necessary for any signs of respiratory distress or significant skin reactions.

Pregnancy and Breastfeeding Considerations

Pregnancy Category C applies to benzonatate, indicating that risk cannot be ruled out. There is insufficient evidence regarding the safety of benzonatate use during pregnancy. It is recommended only when benefits outweigh risks. Consultation with a healthcare provider is essential before initiation in pregnant women.

The effects of benzonatate on breastfeeding infants are unknown. It is undetermined if benzonatate or its metabolites are excreted in human milk. As a precaution, alternative cough treatments should be considered for nursing mothers. A risk-benefit assessment is crucial to ensure the safety of both mother and child.

Possible Tessalon Side Effects

Adverse effects linked to Tessalon are typically mild and include dizziness, headache, sedation, and nausea. In rare cases, severe hypersensitivity reactions can occur. Signs of an allergic reaction include rash, itching, swelling, and difficulty breathing. Immediate medical intervention is critical if these symptoms manifest.

Central nervous system effects such as confusion, hallucinations, or visual disturbances may arise, particularly when exceeding the prescribed dose. Gastrointestinal discomfort and constipation can also occur. Monitoring for side effects is necessary to adjust therapy as needed.

Availability of Non-Prescription Tessalon

Tessalon, including benzonatate 100 mg and 200 mg, is available only via prescription. Due to potential risks associated with its misuse and side effects, it requires professional oversight. Patients should consult healthcare providers to obtain the medication safely and appropriately.

There are no over-the-counter alternatives containing benzonatate. Cough treatments available without a prescription include dextromethorphan-based products. For more comprehensive information on Tessalon, consider this source.

Side Effect	Frequency	Severity
Dizziness	Common	Mild
Allergic Reactions	Rare	Severe
Sedation	Common	Moderate

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